Fixed layout eBooks in ePUB3 are currently supported best with on the iPad. Yes, there are other ways of viewing, but the iPad seems to provide the best user experience.
Many publishers use InDesign somewhere in the process of creating print books.
How can we make use of InDesign to build fixed-layout eBooks?
The step-by-step guide will show how to use InDesign, to begin the process of building fixed-layout eBook. You will also need to be able to edit the CSS and other files inside the ePUB package.
[Edit] Please note that InDesign CC 2014 does now include a means to export to Fixed-Layout ePub, although the markup produced is very complex and is very difficult to edit.
Posted on 10 Apr 2013 around 3pm
I created this flowable eBook by editing the text with Apple Pages. This was exported as MS Word and 'placed' in an InDesign document. After exporting to ePUB3, the file was modified for Apples iBooks and the iBookstore.